Table 3.

Baseline characteristics before and after matching for the rVIII-SingleChain (phase I/III IPD) and rFVIIIFc prophylactic treatment population [14, 16]

	Before matching		After matching
	rVIII-SingleChain	rFVIIIFc	rVIII-SingleChain#	rFVIIIFc
Number of subjects	146†	118‡	146†	118‡
Age (years), mean	29.7	29.0§	29.0	29.0§
Race, % white	69.9	66.9	66.9	66.9
Region, % European	47.3	28.8	28.8	28.8
Weight (kg), mean	74.0	74.0¶	74.0	74.0¶

IPD individual patient data, rFVIII recombinant factor VIII

^†One patient was excluded in the comparison of the annualized rFVIII consumption because of missing data on this outcome. Baseline characteristics for these 145 patients can be found in Supplementary Material Table S4

^‡Individualized prophylaxis arm

^§Mean age was estimated by the assumption that age follows a normal distribution

^¶Mean weight was estimated by the assumption that weight follows a lognormal distribution (reported median 71.65 kg)

^#The effective sample size of rVIII-SingleChain after balancing with the rFVIIIFc population was 123.6