Table 5.
Prognostic models included AAPR and albumin for GBM patients in original cohort
| Clinical variables | Prognostic model (AAPR) | Prognostic model (albumin) | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |||
| LL | UL | LL | UL | |||||
| Gender | ||||||||
| Male | 1 | 1 | ||||||
| Female | 0.649 | 0.466 | 0.904 | 0.011 | 0.662 | 0.475 | 0.922 | 0.015 |
| Adjuvant therapy | ||||||||
| Chemotherapy and radiotherapy | 1 | 1 | ||||||
| Chemotherapy or radiotherapy | 2.763 | 1.852 | 4.122 | <0.001 | 2.972 | 1.985 | 4.452 | <0.001 |
| None | 4.248 | 2.839 | 6.356 | <0.001 | 4.033 | 2.699 | 6.026 | <0.001 |
| Ki67 | ||||||||
| ≥30% | 1 | 1 | ||||||
| <30% | 0.732 | 0.535 | 1.002 | 0.051 | 0.732 | 0.534 | 1.003 | 0.052 |
| IDH-1 | ||||||||
| Mutant | 1 | 1 | ||||||
| Wildtype | 2.265 | 1.347 | 3.809 | 0.002 | 2.405 | 1.420 | 4.074 | 0.001 |
| AAPR | ||||||||
| Low | 1 | |||||||
| High | 0.589 | 0.430 | 0.807 | 0.001 | ||||
| Albumin | ||||||||
| Low | 1 | |||||||
| High | 0.632 | 0.458 | 0.873 | 0.005 | ||||
| C-index | 0.721 | 0.715 | ||||||
| AIC | 1452.24 | 1455.95 | ||||||
Significant findings are expressed in bold and italic.
Abbreviations: HR, hazard ratio; CI, confidence interval; LL, lower limit; UL, upper limit; IDH-1, Isocitrate dehydrogenase-1; AAPR, albumin to alkaline phosphatase ratio; GBM, glioblastoma.