Table 3.

Univariate and multivariate analyses of Cox proportional hazard regression model for PFS in lung cancer patients.

Pathologic parameters	PFS
	HR	95% CI	P-value
Univariate analysis
COL1A1
Positive vs Negative	2.732	1.863-4.006	<0.001
Location
Central type vs Peripheral type	0.965	0.679-1.371	0.841
Tumor diameter
d≤3cm vs 3cm<d≤7cm vs d>7cm	1.849	1.380-2.476	<0.001
Lymph node metastasis
Yes vs No	4.481	2.823-7.111	<0.001
Local invasion
T1-T2 vs T3-T4	2.470	1.476-4.136	0.001
Distant metastasis
Yes vs No	1.828	1.259-2.655	0.002
Pathologic type
LSCC vs LUAD vs SCLC	0.997	0.754-1.317	0.981
Stage
Ⅰ-Ⅱ vs Ⅲ-IV	4.340	2.691-6.998	<0.001
Smoking
Yes vs No	1.434	1.007-2.042	0.046
Multivariate analysis
COL1A1
Positive vs Negative	2.696	1.827-3.980	<0.001
Tumor diameter
d≤3cm vs 3cm<d≤7cm vs d>7cm	1.400	0.913-2.145	0.205
Lymph node metastasis
Yes vs No	4.586	2.916-7.213	<0.001
Local invasion
T1-T2 vs T3-T4	3.483	2.025-5.990	<0.001
Distant metastasis
Yes vs No	1.526	0.977-2.384	0.099
Stage
Ⅰ-Ⅱ vs Ⅲ-IV	0.536	0.211-1.361	0.293
Smoking
Yes vs No	1.488	1.039-2.132	0.030