Skip to main content
. 2021 Jul 30;12(19):5760–5771. doi: 10.7150/jca.51855

Figure 1.

Figure 1

High expression of S100A1 in PTC might be a new biomarker. (A): Immunohistochemistry (IHC) staining of S100A1 was shown in human PTC and normal thyroid tissues. (B): IHC staining score of S100A1 was compared in human PTC and normal thyroid tissues (***P<0.001). (C-D): S100A1 expression was compared in paired samples and population samples in TCGA database, respectively. (*P<0.05). (E): Comparison of the expression of S100A1 in normal thyroid and various PTC subtypes in TCGA. (F): Methylation levels of S100A1 gene promoter in thyroid cancer were lower than normal thyroid based on TCGA data, which were analyzed using UALCAN web. (*P<0.05). (G): Kaplan-Meier analysis showed that a higher expression of S100A1 was associated with a worse recurrence-free survival. (H): Survival analysis was shown based on our follow-up data of 86 patients. (I): ROC curves were shown for discrimination of normal tissues and PTC tissues. An optimal cut-point derived from the maximum of Youden index was displayed as a triangle (Youden index: 0.773; Sensitivity: 82.46%, Specificity: 94.83%). ROC curves for diagnosis in stage I, stage II, stage III, and stage IV patients. PTC, papillary thyroid carcinoma; TCGA, The Cancer Genome Atlas; ROC, receiver operating characteristic; AUC, area under the curve.