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A diagram of the potential underlying regulatory mechanism of S100A1. After phosphorylation and ubiquitination, YAP is degraded by proteasomes in cell cytoplasm. S100A1 could suppress this process, resulting in YAP protein accumulation in cytoplasm and an increase in YAP entering the nucleus, and ultimately induces the transcription of antiapoptotic and proliferative genes. YAP: yes associated protein.
