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. 2021 Mar 22;28(9):2555–2570. doi: 10.1038/s41418-021-00770-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a siRNA targeting TFEB or β-catenin but not Atg7 transfected HeLa cells exhibited impaired cancer cell migration compared with Wnt3a-CM treated cells. Quantification of cell migration ability was shown in the right panel. The statistical analyses represent average values of 3 different areas from a representative experiment. Scale bar, 100 μm. b Western blot analysis revealed that the protein expression of TFEB, β-catenin or ATG7 was reduced after the transfection with each siRNA. c TCGA gene expression data set of breast cancer patients show positive correlation between Axin2 and TFEB-mediated Wnt target gene (ANK2, NAV3, RUNDC3B) but not TFEB-mediated lysosomal gene (MCOLN1). The Correlation coefficients (r) in this figure were calculated by Pearman’s linear correlation. Two-tailed P value was used for analyzing statistical significance d Kaplan–Meier plot shows that high expression of TFEB-mediated Wnt target genes but not lysosomal gene is associated with poor prognosis of breast cancer patients.