Fig. 9. Computational modeling captures observed power and coherence spectra and predicts the observed relationship between hyperdirect pathway structural and functional connectivity.

A Simulated power spectra for the STN, GPi, and cortex are shown with the associated profiles of cortico-STN and cortico-GPi coherence spectra. Parameter values for this simulation are as per Supplementary Table 2, except for the fact that the strength of the net inhibitory loop, W_GIE, between the GPi, thalamus, and cortex was varied as shown. Power and coherence spectra display peaks at high and low beta frequencies, in keeping with experimental data. Increasing W_GIE results in increased low beta frequency power and coherence. The shaded areas represent standard errors of the mean. B The simulated relationship between hyperdirect pathway strength and cortico-STN high beta band coherence displays a monotonically increasing profile. Standard errors of the mean are computed over n = 50 simulations.