Table 2.

The performance of the models for distinguishing the patients with NPC from the controls.

Model	Validation dataset
	AUC	95%CI	Repeated 10-fold	P valuea	P valuea	R2b
Epidemiology model c	0.563	0.529–0.597	0.586	9.03E-26	------d	0.016
Epidemiology + 2 host SNPs modele	0.619	0.585–0.652	0.631	9.37E-23	1.85E-03	0.031
Epidemiology + 2 host SNPs + 3 EBV SNPs modelf	0.772	0.745–0.800	0.770	------d	9.03E-26	0.174

AUC area under the curve, CI confidence interval, repeated 10-fold, average AUC from repeated 10-fold cross-validation.

^a The P value was calculated using a two-sided Delong’s test.

^b McFadden’s Pseudo-R².

^c Epidemiological model: smoking, salted-fish consumption, education and family history of NPC.

^d “–” is a reference model.

^e 2 Host SNPs: rs2860580, rs2894207.

^f 3 EBV SNPs: EBV162215, EBV162476 and EBV163364.