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. 2021 Aug 31;11:17415. doi: 10.1038/s41598-021-96835-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of the reduced core and genome-scale kinetic models obtained by reduction of a mass action kinetic model. The reduced core kinetic model comprises ten components and ten reactions, while the reduced genome scale kinetic model consists of 13 compounds and 16 reactions. (fumarate reductase—FRD2, succinate dehydrogenase—SUCDi). The concentration of the components present in the reduced networks can be used to model the concentration of all other components in the original networks.