Table 5.
Bioinformatic analysis of the studied genetic variants.
| SNP (gene) | rs911160 (AURKA) | rs2289590 (AURKB) | rs11084490 (AURKC) | rs758099 (AURKC) | rs42873 (PLK1) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Alleles | G | C | C | A | C | G | C | T | G | C |
| Transcription factorsa | C/EBPalpha | C/EBPalpha | PEA3 | PEA3 | XBP-1 | XBP-1 | NF-1 | NF-1 | GR-alpha | GR-alpha |
| C/EBPbeta | C/EBPbeta | TFII-I | TFII-I | NF-Y | NF-Y | AP-2alphaA | AP-2alphaA | |||
| GR-beta | GR-beta | YY1 | ENKTF-1 | TFII-I | T3R-beta1 | T3R-beta1 | ||||
| NF-Y | XBP-1 | GATA-1 | c-Jun | |||||||
| NF-1 | CTF | |||||||||
| NFI-CTF | POU2F1 | |||||||||
| PEA3 | ||||||||||
SNP single nucleotide polymorphism.
a Transcription factors binding sites were evaluated using PROMO (ALLGEN) software.
Different transcription factor binding motifs identified for polymorphic alleles of the studied polymorphisms are indicated in bold letters.