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. 2021 Apr 19;2021(4):CD011535. doi: 10.1002/14651858.CD011535.pub4

Yilmaz 2002.

Study characteristics
Methods RCT, placebo‐controlled, open‐label trial
Date of study: unreported
Location: Turkey
Participants Randomised: 50 participants (no description of the study population)
Inclusion/exclusion criteria
  • Not stated


Dropouts and withdrawals
  • Not stated

Interventions Intervention
A. Acitretin (n = 50), orally, 0.5‐0.7 mg/kg, daily
Control intervention
B. Placebo (n = 50).
Co‐intervention
PUVA, twice weekly, 8‐MOP at a dosage of 0.4 ‐ 0.6 g/kg, 2 hours before UVA exposure
Outcomes Time of assessments not stated
Primary or secondary outcomes of the trial
  • Not clearly defined


Outcomes of the trial
  • Complete remission

Notes Funding source: not stated
Declarations of interest: not stated
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote (abstract): "The patients were equally allocated to treatment groups in the study"
Comment: no description of the method used to guarantee random sequence generation
Allocation concealment (selection bias) Unclear risk Quote (abstract): "The patients were equally allocated to treatment groups in the study"
Comment: no description of the method used to guarantee allocation concealment
Blinding of participants and personnel (performance bias)
All outcomes High risk Quote (abstract): "We performed an open, controlled study..."
Comment: not blinded, subjective outcome
Blinding of outcome assessment (detection bias)
All outcomes High risk Quote (abstract): "We performed an open, controlled study..."
Comment: not blinded, subjective outcome
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Randomly assigned 50
Comment: no description of the number of participants analysed, no description of the method used to manage missing data
Selective reporting (reporting bias) Unclear risk Comment: only an abstract available