Table 2. Comparison of the median severity of postmenopausal psychological symptoms before and during the intervention in the two groups.

Psychological disorder		Drug	Placebo	P value (between group)
		Median (IQR)	Median (IQR)
Depressed mood	Before intervention	3 (2, 3)	3 (2, 3)	0.609
	Two weeks later	2 (1, 2)	3 (2, 3)	< 0.001
	Four weeks later	0 (0, 1)	3 (3, 3)	< 0.001
	P value (within group)	< 0.001	< 0.001	-
	Difference during the study	2 (2, 3)	0 (0, 0)	< 0.001
Irritability	Before intervention	3 (2, 3)	2 (2, 3)	0.001
	Two weeks later	2 (2, 2)	2 (2, 2)	0.015
	Four weeks later	1 (1, 1)	2 (2, 3)	< 0.001
	P value (within group)	< 0.001	0.007	-
	Difference during the study	2 (1, 2)	0 (−1, 0)	< 0.001
Anxiety	Before intervention	2 (2, 2)	2 (1, 2)	0.073
	Two weeks later	1 (1, 1)	2 (2, 2)	< 0.001
	Four weeks later	1 (1, 1)	2 (2, 3)	< 0.001
	P value (within group)	< 0.001	0.001	-
	Difference during the study	1 (1, 1)	−1 (−1, 0)	< 0.001
Mental exhaustion	Before intervention	3 (2, 4)	3 (3, 4)	0.361
	Two weeks later	1 (1, 2)	3 (3, 4)	< 0.001
	Four weeks later	1 (0, 1)	4 (3, 4)	< 0.001
	P value (within group)	< 0.001	0.028	-
	Difference during the study	3 (2, 3)	0 (−1, 0)	< 0.001
Total MRS	Before intervention	11 (10, 12)	11 (9, 11)	0.085
	Two weeks later	6 (5, 7)	10 (9, 11)	< 0.001
	Four weeks later	3 (2, 4)	11 (10, 12)	< 0.001
	P value (within group)	< 0.001	< 0.001	-
	Difference during the study	8 (7, 9)	−1 (−2, 0)	< 0.001

IQR: interquartile range, MRS: Menopause Rating Scale.