Table 3.
Histopathological Characteristics Depending on Tumor Location
| Over all | Peripheral ICC | Intermediate ICC | Central ICC | p value | |
|---|---|---|---|---|---|
| N | 65 | 16 (25) | 26 (40) | 23 (35) | - |
| Tumor type | 0.072 | ||||
| Mass forming | 45 (69) | 14 (88) | 20 (77) | 11 (48) | |
| Periductal infiltrating | 14 (22) | 1 (6) | 4 (15) | 9 (39) | |
| Intraductal growth | 6 (9) | 1 (6) | 2 (8) | 3 (13) | |
| Differentiation | 0.667 | ||||
| Well | 17(26) | 6 (38) | 6 (23) | 5 (22) | |
| Moderate | 39 (60) | 7 (44) | 17 (66) | 15 (65) | |
| Poor | 9 (14) | 3 (19) | 3 (12) | 3 (13) | |
| Tumor size | 50.0 (32.0-80.0) | 33.5 (21.0-45.0) | 48.0 (32.8-72.5) | 80.0 (45.0-100.0) | *0.002 |
| Multiple tumor | 8 (12) | 0 (0) | 2 (8) | 6 (26) | *0.033 |
| Serosal invasion | 22 (34) | 2 (13) | 10 (39) | 10 (44) | 0.108 |
| Vascular invasion | 53 (82) | 9 (56) | 24 (92) | 20 (87) | *0.010 |
| Bile duct invasion | *<0.001 | ||||
| 2nd branch of hepatic duct | 14 (22) | 0 (0) | 1 (4) | 13 (57) | |
| 1st branch of hepatic duct | 9 (14) | 0 (0) | 2 (8) | 7 (30) | |
| Common bile duct | 3 (5) | 0 (0) | 0 (0) | 3 (13) | |
| Lymph node metastasis** | 14/38 (37) | 0/4 (0) | 7/16 (44) | 7/18 (39) | 0.26 |
| Resection margin status, R0 | 53 (82) | 14 (88) | 23 (89) | 16 (70) | 0.376 |
| 8th AJCC Stage A and more | 32 (49) | 2 (13) | 15 (58) | 15 (65) | *0.003 |
| 6th LCSGJ Stage and more | 49 (75) | 7 (44) | 23 (89) | 19 (83) | *0.003 |
ICC, Intrahepatic cholangiocarcinoma; AJCC, American joint committee on cancer; LCSGJ, Liver cancer study group of Japan; *p<0.05; ** Regional lymph node metastasis was calculated as lymph node positive patients number among lymph node dissected patients.