Figure 4.

RA Inhibits Hepatoma Cell Invasion. The high invasion capability of hepatoma cells is the main reason for the high refractory and recurrence rates of HCC. Therefore, we tested the effect of RA on hepatoma cell invasion using a Matrigel^® invasion assay. RA significantly inhibited invasion through the Matrigel^®. Compared with the control group, the percentage of invading HepG2 cells was decreased by 21.7%, 60.3%, and 76.4% after treatment with 100, 200, and 400 µM RA for 24 hrs, respectively