Figure 5.

RA Inhibits Hepatoma Cell Invasion. Moreover, we detected the expression of MMP-2 and MMP-9 by western blot. RA dose-dependently inhibited the expression of MMP-2 and MMP-9 in HepG2 cells. Compared with the control group, the expression of MMP-2 in HepG2 cells was decreased by 20.0%, 40.7%, and 62.7%, and that of MMP-9 was decreased by 19.9%, 43.7%, and 70%, after treatment with 100, 200, and 400 µM for 24 h, respectively. These results suggested that RA inhibited hepatoma cell invasion and migration by reducing the expression of MMPs, thereby providing pathways for the invasion and metastasis of hepatoma cells