Table 3.
BioMAP systems and readouts (Plus, 2021).
| System | Relevance | Cell type | Biomarker Readout |
|---|---|---|---|
| /Mphg | Cardiovascular Disease, Chronic Inflammation, Restenosis | Macrophages + HUVECs | CCL2/MCP-1, CCL3/MIP-1 α, CD106/VCAM-1, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, IL-1 α, M−CSF, sIL-10, SRB, SRB-Mphg |
| 3C | Cardiovascular Disease, Chronic Inflammation | HUVECs | CCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD54/ICAM-1, CD62E/E-Selectin, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, Proliferation, SRB |
| 4H | Allergy, Asthma, Autoimmunity | HUVECs | CCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD62P/P-Selectin, CD87/uPAR, SRB, VEGFR2 |
| BE3C | Chronic obstructive pulmonary disease (COPD), Lung Inflammation | Bronchial epithelial cells | CD54/ICAM-1, CD87/uPAR, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, HLA-DR, IL-1 α, Keratin 8/18, MMP-1, MMP-9, PAI-I, SRB, tPA, uPA |
| BF4T | Allergy, Asthma, Fibrosis, Lung Inflammation | Bronchial epithelial cells + Dermal fibroblasts | CCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD54/ICAM-1, CD90, CXCL8/IL-8, IL-1 α, Keratin 8/18, MMP-1, MMP-3, MMP-9, PAI-I, SRB, tPA, uPA |
| BT | Allergy, Asthma, Autoimmunity, Oncology | B cells + Peripheral blood mononuclear cells | B cell Proliferation, PBMC Cytotoxicity, Secreted IgG, sIL-17A, sIL-17F, sIL-2, sIL-6, sTNF-α |
| CASM3C | Cardiovascular Inflammation, Restenosis | Coronary artery smooth muscle cells | CCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, IL-6, LDLR, M−CSF, PAI-I, Proliferation, Serum Amyloid A, SRB |
| HDF3CGF | Chronic Inflammation, Fibrosis | Dermal fibroblasts | CCL2/MCP-1, CD106/VCAM-1, CD54/ICAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, M−CSF, MMP-1, PAI-I, Proliferation_72hr, SRB, TIMP-1, TIMP-2 |
| KF3CT | Dermatitis, Psoriasis | Dermal fibroblasts + Keratinocytes | CCL2/MCP-1, CD54/ICAM-1, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, IL-1 α, MMP-9, PAI-I, SRB, TIMP-2, uPA |
| LPS | Cardiovascular Disease, Chronic Inflammation | Peripheral blood mononuclear cells + HUVECs | CCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, IL-1 α, M−CSF, sPGE2, SRB, sTNF-α |
| MyoF | Chronic Inflammation, Fibrosis, Matrix Remodeling, Wound Healing | Lung fibroblasts | bFGF, CD106/VCAM-1, Collagen I, Collagen III, Collagen IV, CXCL8/IL-8, Decorin, MMP-1, PAI-I, SRB, TIMP-1, α-SM Actin |
| SAg | Autoimmune Disease, Chronic Inflammation | Peripheral blood mononuclear cells + HUVECs | CCL2/MCP-1, CD38, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, CXCL9/MIG, PBMC Cytotoxicity, Proliferation, SRB |