Table 6.

Cigarette and NGP activities in the BioMAP platform. Changes in key biomarker activities are listed by biomarker and biological disease classifications.

Biological and disease relevance activity	Decreased biomarker activity	Increased biomarker activity	Modulated activity*
3R4F
Inflammation-related activities	MIP-1, sTNFα, VCAM-1, Eot3	sPGE2, IL-1α, IL-8	_
Immunomodulatory activities	M−CSF, sIL-10, sIL-2, sIL-6, CD40, sIL-17A	–	_
Tissue remodeling activities	–	EGFR	_
Haemostasis-related activities	–	TM, TF	_
HTP
Immunomodulatory activities	M−CSF	sIL-10	_
Tissue remodeling activities	EGFR	–	_
HYB
Tissue remodeling activities	–	EGFR	_
EVP
Immunomodulatory activities	–	sIL-10	_
Tissue remodeling activities	EGFR, Col-I	–	_

*Biomarker key activities were described as modulated if these activities increased in some systems but decreased in others.