表4. 影响181例CRO感染患者30 d死亡的单因素和多因素分析.
变量 | 单因素分析 |
多因素分析 |
||||
OR | 95%CI | P值 | OR | 95%CI | P值 | |
移植 | 0.350 | 0.174~0.704 | 0.003 | 0.791 | 0.338~1.847 | 0.587 |
确诊CRO前非CR | 2.758 | 1.281~5.936 | 0.009 | 1.533 | 0.708~3.318 | 0.278 |
确诊CRO前化疗强度 | ||||||
加大剂量 | 0.390 | 0.200~0.760 | 0.006 | 0.727 | 0.346~1.528 | 0.400 |
减低剂量 | 0.478 | 0.042~5.463 | 0.552 | 0 | 0 | 0.979 |
常规剂量(参照) | 1 | |||||
确诊CRO前住院时间>7d | 2.336 | 1.155~4.728 | 0.018 | 1.340 | 0.692~2.598 | 0.385 |
确诊CRO时PCT>0.2ng/ml | 3.341 | 1.562~7.148 | 0.002 | 2.670 | 1.324~5.385 | 0.006 |
确诊CRO时体温>39.5°C | 2.252 | 1.219~4.160 | 0.010 | 1.523 | 0.895~2.593 | 0.121 |
确诊CRO后抗菌治疗方案 | ||||||
替加环素为基础 | 1.608 | 0.599~4.314 | 0.346 | 1.378 | 0.640~2.966 | 0.413 |
多黏菌素为基础 | 1.326 | 0.526~3.343 | 0.549 | 1.727 | 0.814~3.663 | 0.155 |
β内酰胺类为基础 | 0.368 | 0.152~0.891 | 0.027 | 0.656 | 0.301~1.429 | 0.289 |
单药治疗 | 0.491 | 0.174~1.388 | 0.180 | 1.028 | 0.402~2.631 | 0.954 |
其他联合 | 0.553 | 0.046~6.595 | 0.639 | 0 | 0 | 0.979 |
替加环素+多黏菌素为基础(参照) | 1 | |||||
亚胺培南MIC≥16µg/ml | 7.507 | 2.786~20.230 | <0.001 | 4.197 | 1.298~13.569 | 0.017 |
注:CRO:碳青霉烯耐药革兰阴性菌;CR:完全缓解;PCT:降钙素原;MIC:最低抑菌浓度