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Schematic of Stat1 domain structure and Stat1-ER chimera. Domains shown include the interaction domain (ID), which is responsible for interaction with other transcription factors including other STATs, the DNA-binding domain (DBD), the SH2 domain (SH2), which mediates STAT dimerization, the tyrosine that is phosphorylated upon cytokine stimulation (Y), the transcriptional activation function (AF) and, for the chimeric construct, the ER LBD (ER-LBD).
