Table 1.

Distribution of identified somatic variations

Tissue source	Patient ID	All somatic variants			Somatic driver variants
		UTR3	UTR5	Exonic	UTR3	UTR5	Exonic
Tumor tissue	P1	2,217	365	13	103	18	2
	P2	2,488	426	13	127	23	0
	P4	2,238	439	7	95	20	0
	P5	2,589	453	13	130	22	0
	P6	2,141	419	6	88	17	0
Urine exosomes	P1	3,442	470	25	188	28	1
	P2	2,189	345	25	105	22	2
	P4	287	75	93	7	4	3
	P5	1,215	192	23	85	4	3
	P6	1,229	172	30	55	11	2
Serum exosomes	P1	118	44	62	5	5	1
	P2	1,047	175	62	72	16	1
	P4	460	141	68	19	5	4
	P5	766	142	8	57	11	1
	P6	150	48	52	6	3	2

In the discovery-based approach, somatic variants in all samples were identified by filtering against all variants found in the normal tissue (PBMC) sequence, followed by using the minor allelic frequency (MAF) test. P1–P6, patients 1–6.