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. 2021 Jun 30;40(17):e107586. doi: 10.15252/embj.2020107586

Figure 1. CRMP4 is elevated in ALS‐diseased spinal cord neurons.

Figure 1

  • A, B
    (A) Representative IHC images and (B) semi quantification of CRMP4 protein in human spinal cords (SC) cross sections from 2 controls and 3 ALS patients. We analyzed total of 7 SC sections of controls and 14 SC sections of ALS patients, data presented as mean ± SE. DAB: labeled CRMP4. Scale bar: left images 20 µm, right insets 10 µm. Mann‐Whitney test ***P = 0.0003.
  • C
    Representative images of P90 SC cross sections of SOD1G93A and WT mice. Red: denotes NeuN, Green: denotes CRMP4. Scale bar: 10 μm.
  • D
    Quantification of the percentage of CRMP4‐positive SC neurons in 3 WT VS. 3 SOD1G93A mice. We monitored CRMP4 expression in total of 108 cells in WT condition and 123 cells in SOD1G93A, an average of 36 or 41 cells in each repeat respectively. Student's t‐test, n = 3, data presented as mean ± SE, *P = 0.0161.