Fig. 4.

Proliferation and survival of Cp-deficient oligodendrocytes. (A, C and E) Representative coronal sections from control and Sox10-Cp^KO brains at P15 and P30 immunostained for Olig2, Ki67, Sox2 and caspase-3. Scale bar = 90 μm. Arrowheads in high magnification insets indicate examples of double positive cells that were selected for the analysis. Scale bar = 30μm. (B, D and F) Olig2/Ki67, Olig2/Sox2 and Olig2/Casp3 double-positive cells were quantified in the somatosensory cortex (CX) and central corpus callosum (CC) at P15 and P30. Scatter dot-plot graphs are showing single brain slices values plus mean ± SD. ***p < 0.001 vs. respective controls.