Table 4. Performance on WISC-IV Indices by Sex and Genetic Status in Overall Sample.
| WISC-IV index | WISC-IV index standard score, mean (95% CI)a | |||
|---|---|---|---|---|
| With PSEN1 variant | Without PSEN1 variant | |||
| Boys (n = 124) | Girls (n = 141) | Boys (n = 535) | Girls (n =554) | |
| Verbal comprehension | 88.50 (86.44-90.57) | 91.69 (89.75-93.62) | 88.88 (87.89-89.88) | 89.94 (88.97-90.92) |
| Perpetual reasoning | 91.46 (89.50-93.42) | 93.94 (92.10-95.77) | 91.66 (90.71-92.60) | 92.59 (91.68-93.52) |
| Working memory | 88.78 (86.86-90.70) | 93.75 (91.95-95.55) | 91.77 (90.85-92.70) | 92.22 (91.32-93.13) |
| P valueb | NA | .001 | .04 | .009 |
| Processing speed | 85.77 (83.76-87.79) | 88.18 (86.29-90.07) | 88.10 (87.14-89.08) | 87.58 (86.62-88.53) |
Abbreviations: PSEN1, presenilin 1; WISC-IV, Wechsler Intelligence Scale for Children, Fourth Edition.
a
Data are reported as mean (95% CI) based on modified marginal means for the model with the covariates and P value for the univariate general linear model.
b
P values are calculated compared with boys with the PSEN1 E280A variant using Bonferroni correction. Calculated using general linear model with urbanity, education, and socioeconomic status entered as covariates and PSEN1 genetic status, sex, and the interaction of genetic status and sex entered as fixed factors.