Table I.

Gene mutational profile in a patient with lung adenocarcinoma by next-generation sequencing of DNA obtained from surgical specimens.

Genes	Mutation sites	Frequency, %	Amplification (copy no.)
HER2	F616La	1.46	11
ErbB4	N280I	24.41
GATA1	S12P	1.17
GNAS	T386P	1.82
KIT	M1R	2.58
KIT	A621S	21.79
MSH3	K281fs	1.73
TP53	G154V	33.57
VEGFA	L139R	1.08

^aThis mutation is not a classic activating mutation and unlikely to be responsible for the responsiveness to HER2-targeted therapy.