TABLE 1.
Spontaneous recombination and mutation ratesa
| Relevant genotype | Recombination rate (10−8) | lys2ΔBgl reversion rate (10−9) | Canr rate (10−7) |
|---|---|---|---|
| WT | 5.3 (1.0) | 3.2 (1.0) | 1.2 (1.0) |
| ntg1 ntg2 | 5.5 (1.1) | 2.2 (0.8) | 1.5 (1.3) |
| apn1 | 10 (1.9) | 3.8 (1.2) | 2.1 (1.8) |
| ntg1 ntg2 apn1 | 93 (18) | 8.2 (2.6) | 13 (11) |
| rad1 | 6.8 (1.3) | 5.9 (1.8) | 2.1 (1.8) |
| ntg1 ntg2 rad1 | 8.2 (1.5) | 11 (3.4) | 5.5 (4.6) |
| apn1 rad1 | 25 (4.7) | 23 (7.2) | 9.8 (8.2) |
| ntg1 ntg2 apn1 rad1 | 890 (170) | 350 (110) | 74 (62) |
| rad52 | ND | 22 (6.9) | 8.5 (7.1) |
| ntg1 ntg2 apn1 rad52 | ND | 120 (38) | 180 (150) |
| rev3 | 9.1 (1.7) | 1.5 (0.5) | 0.81 (0.7) |
| ntg1 ntg2 apn1 rev3 | 310 (58) | 2.2 (0.7) | 2.4 (2.0) |
a
Rates are expressed as recombinants or mutants per cell per generation. Numbers in parentheses indicate the fold increase over wild type values. WT, wild type; ND, not determined.