Figure 5. Serum creatinine (Cre) concentrations before and after first-line chemotherapy for patients treated with reduced-dose gemcitabine plus cisplatin (GC-r, n=10) or full-dose gemcitabine plus carboplatin (G-Car-f, n=24). Patients who discontinued the regimen after the first cycle are shown in red. p-Values were determined by the Wilcoxon ranked sign test.