Table 1.
Patient Characteristics for the Entire Cohort and 3 Subgroups
| Characteristics | Entire Cohort (n = 1837) | Subgroups | P | ||
|---|---|---|---|---|---|
| HIV-Infected MSM (n = 1504) |
HIV-Uninfected MSM (n = 155) |
HIV-Infected Women (n = 178) |
|||
| Age, y, median (IQR) | 45 (34–54) | 45 (34–54) | 37 (31–48) | 52 (44–57) | <.001 |
| Race/ethnicity | |||||
| White | 691 (38) | 586 (39) | 90 (58) | 15 (8) | <.001 |
| African American | 293 (16) | 222 (14) | 10 (7) | 71 (40) | |
| Hispanic | 357 (19) | 302 (20) | 9 (6) | 46 (26) | |
| Other | 252 (14) | 210 (14) | 26 (17) | 16 (9) | |
| Unknown | 244 (13) | 193 (13) | 20 (13) | 30 (17) | |
| Current smoker | 394 (21) | 310 (21) | 19 (12) | 65 (37) | <.001 |
| HIV RNA < 100 copies/mL | 1510 (92) | 1363 (92) | … | 147 (85) | .003 |
| CD4+ T-cell count ≥ 500 cells/mL | 1136 (71) | 1025 (72) | … | 111 (66) | .11 |
| Receptive anal intercourse | 1773 (97) | 1502 (99) | 155 (100) | 116 (65) | <.001 |
| Anal cytology | |||||
| Unsatisfactory | 66 (4) | 52 (3) | 7 (5) | 7 (4) | .19 |
| Benign | 410 (22) | 325 (22) | 42 (27) | 43 (24) | |
| ASCUS | 716 (39) | 577 (38) | 62 (40) | 77 (43) | |
| LSIL | 525 (29) | 443 (30) | 40 (26) | 42 (24) | |
| ASC-H | 44 (2) | 42 (3) | 1 (1) | 1 (1) | |
| HSIL | 76 (4) | 65 (4) | 3 (2) | 8 (4) | |
| Anal hrHPV DNA testing | |||||
| Any hrHPV positive | 1514 (82) | 1248 (83) | 130 (84) | 136 (76) | .08 |
| HPV16/18 positive | 679 (37) | 550 (37) | 63 (41) | 66 (37) | .61 |
| Others positivea | 1420 (77) | 1186 (79) | 115 (74) | 119 (67) | .001 |
| Biopsy-proven HSIL and cancer | 756 (41)b | 646 (43) | 55 (36) | 55 (31) | .003 |
Data are No. of cases (%) unless otherwise indicated.
Abbreviations: ASC-H, atypical squamous cells, cannot exclude HSIL; ASCUS, atypical squamous cells of uncertain significance; HIV, human immunodeficiency virus; hrHPV, high-risk human papilloma virus; HSIL, high-grade squamous intraepithelial lesion; IQR, interquartile range; LSIL, low-grade squamous intraepithelial lesion; MSM, men who have sex with men.
aOthers include HPV31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68.
bFour patients were diagnosed with superficially invasive squamous cell carcinoma of the anus.