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. 2000 Oct 23;2000(4):CD001921. doi: 10.1002/14651858.CD001921

Comparison 1. Eversion vs conventional CEA.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 perioperative stroke and/or death 4 2363 Odds Ratio (M‐H, Random, 95% CI) 0.44 [0.10, 1.82]
2 perioperative death 4 2363 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.86 [0.31, 2.37]
3 perioperative stroke 4 2363 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.70 [0.38, 1.29]
4 perioperative stroke large vs small trials 4 2363 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.70 [0.38, 1.29]
4.1 large trials 1 1353 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.15 [0.54, 2.43]
4.2 small trials 3 1010 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.24 [0.08, 0.71]
5 perioperative stroke; sample size calculated : yes vs no 4 2363 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.70 [0.38, 1.29]
5.1 sample size yes 2 1917 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.88 [0.46, 1.71]
5.2 sample size no 2 446 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.13 [0.02, 0.74]
6 perioperative stroke blinding vs no blinding 4 2363 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.70 [0.38, 1.29]
6.1 blinding 3 1799 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.82 [0.41, 1.64]
6.2 poor blinding 1 564 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.35 [0.09, 1.42]
7 perioperative disabling stroke 4 2363 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.56 [0.25, 1.23]
8 perioperative ipsilateral stroke 3 1799 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.92 [0.44, 1.93]
9 perioperative stroke and/or death: sample size yes 4 2363 Odds Ratio (M‐H, Random, 95% CI) 0.44 [0.10, 1.82]
9.1 sample size: yes 2 1917 Odds Ratio (M‐H, Random, 95% CI) 0.68 [0.20, 2.32]
9.2 sample size: no 2 446 Odds Ratio (M‐H, Random, 95% CI) 0.06 [0.00, 1.08]
10 perioperative stroke and/or death quality of randomisation 4 2363 Odds Ratio (M‐H, Random, 95% CI) 0.44 [0.10, 1.82]
10.1 class A studies (adequate concealment) 3 1799 Odds Ratio (M‐H, Random, 95% CI) 0.36 [0.02, 6.84]
10.2 class B studies (unadequate concealment) 1 564 Odds Ratio (M‐H, Random, 95% CI) 0.32 [0.08, 1.18]
11 early carotid occlusion 4 2025 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.62 [0.24, 1.58]
12 neck hematoma 4 2389 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.76 [0.52, 1.11]
13 cranial nerve injuries 4 2025 Odds Ratio (M‐H, Random, 95% CI) 0.52 [0.22, 1.23]
14 myocardial infarction 2 1663 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.79 [0.21, 2.92]
15 stroke during follow‐up (excluding perioperative) 3 2212 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.84 [0.43, 1.64]
16 ipsilateral stroke during follow‐up (excl. perioperative) 2 1652 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.16 [0.73, 6.45]
17 restenosis/occlusion best 5 2557 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.48 [0.32, 0.72]
18 restenosis/occlusion worst 5 2537 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.78 [0.54, 1.13]
19 restenosis quality blinding 5 2557 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.48 [0.32, 0.72]
19.1 adequate blinding 4 1997 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.39 [0.24, 0.61]
19.2 unadequate blinding 1 560 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.06 [0.45, 2.54]
20 restenosis sample size 5 2557 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.48 [0.32, 0.72]
20.1 large sample 2 1904 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.63 [0.40, 0.99]
20.2 small sample size 3 653 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.18 [0.07, 0.43]
21 restenosis large vs small trials 5 2557 Odds Ratio (M‐H, Random, 95% CI) 0.44 [0.19, 1.02]
21.1 large trials 1 1344 Odds Ratio (M‐H, Random, 95% CI) 0.50 [0.29, 0.88]
21.2 small trials 4 1213 Odds Ratio (M‐H, Random, 95% CI) 0.29 [0.06, 1.44]
22 restenosis quality of randomisation 5 2557 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.48 [0.32, 0.72]
22.1 class A studies (adequate concealment) 3 1810 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.38 [0.24, 0.61]
22.2 class B studies (unadequate concealment) 2 747 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.96 [0.42, 2.16]
23 all strokes during follow‐up and perioperative deaths 3 2238 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.84 [0.48, 1.47]
24 ipsilateral stroke during follow‐up and perioperative deaths 2 1674 Odds Ratio (M‐H, Random, 95% CI) 0.71 [0.02, 22.08]
25 perioperative stroke and/or death (separate analysis) 5 2563 Odds Ratio (M‐H, Random, 95% CI) 0.49 [0.19, 1.29]
26 ipsilateral stroke during follow‐up (separate analysis) 4 1983 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.16 [0.73, 6.45]
27 stroke during follow‐up (separate analysis) 4 2407 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.84 [0.43, 1.64]
28 perioperative disabling stroke (separate analysis) 5 2563 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.57 [0.28, 1.17]
29 perioperative stroke (separate analysis) 5 2563 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.62 [0.35, 1.09]
30 perioperative death (separate analysis) 5 2563 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.80 [0.33, 1.93]
31 perioperative stroke and/or death (separate analysis. 2) 3 2227 Odds Ratio (M‐H, Random, 95% CI) 0.44 [0.10, 1.82]