Table 1.
Cohort Demographics, n = 178 patients
| Variable | Number (percentage) |
|---|---|
| Gender | |
| Female | 62 (34.8%) |
| Male | 116 (65.2%) |
| Mean age at surgery | 10.2 years (SD 5.0) |
| Median follow-up | |
| All patients (n = 178) PFS patients (n = 60) |
19.6 months (0.4-72.8) 23.1 months (0.4-70.7) |
| Tumor location | |
| Midline | 137 (77%) |
| Lateral | 41 (23%) |
| Tumor subgroups | |
| WNT | 29 (16.3%) |
| SHH | 34 (19.1%) |
| Group 3 | 37 (20.8%) |
| Group 4 | 67 (37.6%) |
| Unclassified | 11 (6.2%) |
| CSF diversion | |
| Yes | 80 (44.9%) |
| No | 98 (55.1%) |
| Surgical center | |
| High volume | 72 (40.4%) |
| Low volume | 106 (59.6%) |
| Clinical subgroups | |
| PFS1 | 40 (22.5%) |
| PFS2 | 20 (11.2%) |
| Ataxia (grade 3) + behaviora | 6 (3.4%) |
| Ataxia (grade 3) | 11 (6.2%) |
| Ataxia (grade 1-2) | 78 (43.8%) |
| Minor deficit without ataxia | 2 (1%) |
| Normal | 21 (11.8%) |
Abbreviations: CSF, cerebrospinal fluid; PFS1, posterior fossa syndrome with complete mutism; PFS2, posterior fossa syndrome with partial mutism; SHH, Sonic Hedgehog; WNT, wingless-related integration site.
aInability to walk and significant emotional lability and irritability.