TABLE 2.
Maternal 25(OH)D concentrations by BMI category throughout pregnancy and in umbilical cord at birth in each treatment group1
| Baseline | 28 gestational wk | 36 gestational wk | Umbilical cord | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 µg/d (n = 118) | 20 µg/d (n = 121 | P value | 10 µg/d (n = 118) | 20 µg/d (n = 121 | P value | 10 µg/d (n = 118) | 20 µg/d (n = 121 | P value | 10 µg/d (n = 31 | 20 µg/d (n = 31 | P value | |
| 25(OH)D, nmol/L | ||||||||||||
| All | 52.2 ± 22.9 | 52.0 ± 20.5 | 0.920 | 69.5 ± 25.6 | 82.8 ± 30.7 | <0.001 | 80.8 ± 28.2 | 94.4 ± 33.2 | <0.001 | 33.4 ± 12.8 | 36.4 ± 14.7 | <0.001 |
| Normal weight (n = 80) | 55.9 ± 26.3 | 59.2 ± 19.8 | 0.516 | 71.4 ± 23.8 | 91.9 ± 27.8 | <0.001 | 85.7 ± 25.0 | 106.7 ± 31.1 | <0.001 | 35.6 ± 12.6 | 43.0 ± 14.3 | <0.001 |
| Overweight (n = 79) | 51.0 ± 22.2 | 48.7 ± 18.7 | 0.620 | 72.9 ± 25.8 | 81.6 ± 29.6 | <0.001 | 81.9 ± 24.9 | 93.9 ± 31.3 | <0.001 | 33.8 ± 11.0 | 35.4 ± 14.0 | 0.005 |
| Obese (n = 80) | 49.7 ± 19.7 | 48.0 ± 21.2 | 0.716 | 64.3 ± 27.0 | 74.6 ± 32.2 | 0.092 | 74.8 ± 30.6 | 82.1 ± 33.4 | 0.480 | 30.7 ± 14.1 | 30.7 ± 12.8 | 0.855 |
1
Data are means ± SD. P differences in 25(OH)D between 10-µg/d and 20-µ/d treatment groups were assessed using a general linear model, adjusted for baseline 25(OH)D at 28 and 36 gestational wk and umbilical cord. Data at 28 and 36 gestational wk include imputed data; blood samples available for analysis at 28 gestational wk were n = 78 and n = 80, and at 36 gestational wk were n = 73 and n = 80, in the 10-µg/d and 20-µg/d treatment groups, respectively.