Table 1.
Patients Characteristics
| Dose-Escalation Trial Cohort | Non-Trial Cohort | P Value | |
|---|---|---|---|
| Count | |||
| N | 26 | 23 | |
| Age | |||
| Median (IQR) | 62 (56, 67) | 55 (52, 59) | .02 |
| Gender | |||
| Female | 10 (38.5) | 7 (30.4) | |
| Male | 16 (61.5) | 16 (69.6) | .76 |
| ECOG | |||
| 0 | 6 (23.1) | 8 (34.8) | |
| 1 | 18 (69.2) | 11 (47.8) | |
| 2 | 2 (7.7) | 4 (17.4) | .35 |
| Physical dose | |||
| Median (IQR) | 75 (75, 75) | 60 (60, 72) | <.001 |
| Extent of surgery | |||
| Biopsy | 3 (11.5) | 4 (17.4) | |
| Subtotal resection | 8 (30.8) | 9 (39.1) | |
| Gross total resection | 15 (57.7) | 10 (43.5) | .67 |
| MGMT methylation | |||
| Positive | 6 (23.1) | 6 (26.1) | |
| Negative | 19 (73.1) | 9 (39.1) | |
| Unknown | 1 (3.8) | 8 (34.8) | .002 |
| IDH status | |||
| Mutant | 1 (3.8) | 2 (8.7) | |
| Wild-type | 24 (92.3) | 17 (73.9) | |
| Unknown | 1 (3.8) | 4 (17.4) | .22 |
Abbreviations: ECOG, Eastern Cooperative Oncology Group; IDH, isocitrate dehydrogenase; IQR, interquartile range; MGMT, O6-methylguanine-DNA methyltransferase.