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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Respir Physiol Neurobiol. 2019 Jul 25;269:103250. doi: 10.1016/j.resp.2019.103250

Figure 5. Acute lung injury does not alter the intrinsic excitability of perforated whole cell patched 2nd-order nTS neurons.

Figure 5.

A. Representative F–I traces from perforated whole cell patched 2nd-order nTS neurons in saline (Black) and Bleo (Red) showing action potentials in response to increasing current until depolarization block is reached. B-E. (B) There was no significant difference in the rheobase current (P=0.85), which is the minimal current required to generate an action potential, between Bleo and saline treated groups. (C) There was also no significant difference in the maximum current required to produce a depolarization block, thereby terminating action potential generation (P=0.57). (D) There was a significant different in the action potential firing frequency at the rheobase current (P<0.05) between Bleo and saline treated rats. (E) However there was no significant different in the maximum current (P=0.47) between Bleo and saline treated rats. (F) There was no significant difference in the input resistance between Bleo and saline treated rats (P=0.23). Bleo treated group had n=21 neurons, 15 slices, 15 rats, and in the saline group n=10 neurons, 8 slices, 8 rats. Data presented as mean ± standard deviation.