. 2021 Sep 1;7:30. doi: 10.1186/s40780-021-00213-y

Table 2.

Characteristics of case-control studies included in the present meta-analysis

Study	Country	Sample size (case/control)	Age	Female (%)	Anatomical site of fracture	AC burden scale	AC exposure	Adjusted for confounders
Chatterjee et al. (2016) [19]	USA	202,260 (40,452/161,808)	81.1 ± 7.4 yr	85	hip or femur	ADS	prescribed 30–90 days before fracture	age, sex, medications, race, medications (cardiovascular drugs, antidepressants, anticonvulsants, antipsychotics, and benzodiazepines), and comorbidities (dementia, mood disorders, anxiety, schizophrenia, Parkinson’s disease, insomnia, cerebrovascular events, osteoarthritis, osteoporosis, rheumatoid arthritis), and duration of depression
Machado-Duque et al. (2018) [38]	Colombia	900 (300/600)	81.6 ± 8.9 yr	71	hip	ARS	prescribed 30 days before fracture	use of statins, proton pump inhibitors, corticosteroids, oral antidiabetics, polypharmacy (≥ 5 drugs), and treatment city

Study

Country

Sample size
(case/control)

Age

Female
(%)

Anatomical site of fracture

AC burden scale

AC exposure

Adjusted for confounders

Chatterjee et al. (2016) [19]

USA

202,260

(40,452/161,808)

81.1 ± 7.4 yr

hip or femur

ADS

prescribed 30–90 days before fracture

age, sex, medications, race, medications (cardiovascular drugs, antidepressants, anticonvulsants, antipsychotics, and benzodiazepines), and comorbidities (dementia, mood disorders, anxiety, schizophrenia, Parkinson’s disease, insomnia, cerebrovascular events,

osteoarthritis, osteoporosis, rheumatoid arthritis), and duration of depression

Machado-Duque et al. (2018) [38]

Colombia

900

(300/600)

81.6 ± 8.9 yr

hip

ARS

prescribed 30 days before fracture

use of statins, proton pump inhibitors, corticosteroids, oral antidiabetics, polypharmacy (≥ 5 drugs), and treatment city

AC anticholinergic, ARS anticholinergic risk scale, ADS anticholinergic drug scale