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. 2021 Sep 1;22:252. doi: 10.1186/s13059-021-02469-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — AMULET identifies heterotypic and homotypic snATAC-seq multiplets in primary human tissues. a Summary of snATAC-seq samples generated and used in this study from human PBMCs and islets. b Valid read pair distributions for PBMC and islet snATAC-seq samples. c PBMC clusters were annotated based on their correlations with sorted bulk ATAC-seq data. d All multiplets (heterotypic and homotypic) detected by AMULET in PBMC1. Selected multiplets refer to multiplets for which aggregated profiles are shown in panel f of this figure. e The number of cells and percentage of multiplets detected by AMULET in PBMC and islet samples. f Chromatin accessibility profiles of CD4⁺ T, myeloid, and selected multiplets around for T cell marker gene (CD3G) and myeloid cell marker gene (LYZ). CD4⁺ T and myeloid cells show strong accessibility signals for their relevant marker genes while selected multiplets have accessible chromatin for both marker genes