Table 3.
Results of univariate and multivariable analyses of prognostic factors for disease-free survival (DFS) in 148 patients with oral tongue squamous cell carcinoma receiving surgical resection
| Parameters | Number of patients | Univariate analysis | Multivariable analysis | |||
|---|---|---|---|---|---|---|
| DFS (months) | P value | HR (95% CI) | P value | |||
| Age | ||||||
| <53y/o | 70 (47%) | 50.2 | 0.27 | |||
| ≧53y/o | 78 (53%) | 36.7 | ||||
| Sex | ||||||
| male | 135 (91%) | 38.8 | 0.15 | |||
| female | 13 (9%) | NR | ||||
| Pathological T status | ||||||
| T1 + T2 | 90 (61%) | 69.8 | 0.004* | |||
| T3 + T4 | 58 (39%) | 11.4 | ||||
| Pathological N status | ||||||
| N0 | 79 (53%) | 87.9 | < 0.001* | |||
| N1 + 2 + 3 | 69 (47%) | 13.2 | ||||
| Pathological 8th AJCC Stage | ||||||
| I + II | 60 (41%) | NR | 0.001* | |||
| III + IV | 88 (59%) | 13.4 | ||||
| Histologic grade | ||||||
| 1 | 84 (57%) | 57.7 | 0.08 | |||
| 2 + 3 | 64 (43%) | 23.3 | ||||
| Vascular invasion | ||||||
| Absent | 124 (84%) | 52.6 | 0.018* | |||
| Present | 24 (16%) | 11.0 | ||||
| Perineural invasion | ||||||
| Absent | 81 (55%) | 77.5 | 0.008* | |||
| Present | 67 (45%) | 14.0 | ||||
| Extracapsular extension | ||||||
| Absent | 111 (75%) | 64.5 | < 0.001* | |||
| Present | 37 (25%) | 7.9 | 2.22 (1.42–3.47) | < 0.001* | ||
| Surgical margin | ||||||
| Negative | 137 (93%) | 45.9 | 0.08 | |||
| Positive | 11 (7%) | 12.8 | ||||
| Smoking history | ||||||
| Absent | 26 (18%) | NR | 0.07 | |||
| Present | 122 (82%) | 33.0 | ||||
| Alcohol history | ||||||
| Absent | 30 (20%) | 47.3 | 0.54 | |||
| Present | 118 (80%) | 33.0 | ||||
| Betel-nut chewing history | ||||||
| Absent | 36 (24%) | 45.9 | 0.29 | |||
| Present | 112 (76%) | 38.8 | ||||
| UTX expression | ||||||
| Overexpression | 64 (43%) | 20.6 | 0.006* | 1.61 (1.05–2.45) | 0.028* | |
| Low expression | 84 (57%) | 69.8 | ||||
AJCC, American Joint Committee on Cancer. NR, not reach; HR, hazard ratio; CI, confidence interval. *Statistically significant