Table 2.
The changes of lymphocyte subsets, thyroid function indexes and PD-1 among NG&HT, PTC&noHT and PTC&HT
| NG&HT (n = 10) | PTC&noHT(n = 83) | PTC&HT (n = 49) | P | P1 | P2 | P3 | |
|---|---|---|---|---|---|---|---|
| Laboratory Routine Data | |||||||
| Total T(%) | 60.92 ± 6.31 | 63.49 ± 8.49 | 62.38 ± 7.63 | 0.565 | 0.451 | 0.706 | 0.387 |
| CD3+CD4+(%) | 31.82 ± 3.39 | 37.24 ± 6.79 | 36.39 ± 5.93 | 0.132 | 0.047 | 0.093 | 0.523 |
| CD3+CD8+(%) | 26.10 ± 7.40 | 22.99 ± 7.40 | 22.56 ± 5.46 | 0.443 | 0.273 | 0.201 | 0.614 |
| CD4+/CD8+(%) | 1.21[0.90,1.78] | 1.64 [1.19,2.37] | 1.69 [1.25,2.18] | 0.235 | |||
| CD4+ HLA-DR+(%) | 7.37 ± 3.90 | 5.96 ± 2.06 | 6.34 ± 2.10 | 0.266 | 0.128 | 0.417 | 0.250 |
| CD8+ HLA-DR+(%) | 7.98 ± 3.96 | 6.6.5 ± 3.88 | 6.60 ± 2.84 | 0.633 | 0.376 | 0.341 | 0.834 |
| CD8+CD38+(%) | 8.96 ± 8.01 | 5.42 ± 2.81 | 5.70 ± 2.82 | 0.032* | 0.009* | 0.016* | 0.694 |
| NK(%) | 23.05 ± 8.70 | 17.24 ± 8.20 | 18.23 ± 8.47 | 0.233 | 0.100 | 0.186 | 0.484 |
| B(%) | 10.85 ± 2.89 | 14.58 ± 5.10 | 15.33 ± 4.71 | 0.080 | 0.075 | 0.029* | 0.281 |
| T3(nmol/L) | 1.21[1.15, 1.24] | 1.20[1.07, 1.28] | 1.16[1.06, 1.30] | 0.472 | |||
| T4(nmol/L) | 8.50[6.90,9.00] | 8.20 [6.44,9.10] | 8.20 [6.00,9.25] | 0.991 | |||
| FT3(pmol/L) | 3.28 ± 0.23 | 3.39 ± 0.37 | 3.32 ± 0.48 | 0.568 | 0.563 | 0.873 | 0.331 |
| FT4(pmol/L) | 1.29 ± 0.17 | 1.30 ± 0.18 | 1.35 ± 0.20 | 0.350 | 0.882 | 0.466 | 0.162 |
| TSH (μIU/mL) | 1.98[1.49, 4.69] | 1.43[1.02, 1.94] | 1.79[1.17, 2.46] | 0.155 | |||
| TGAb (IU/mL) | 218.0[29.0,489.0] | 18.0[15.00,23.0] | 125.0[33.0,243.5] | 0.000* | 0.000* | 0.543 | 0.000* |
| TPO (IU/mL) | 996.5[291.0,1300.0] | 28.0[28.0,37.5] | 258.0[36.0,909.0] | 0.000* | 0.001* | 0.165 | 0.000* |
| CD3+ PD-1+ (%) | 7.70 ± 2.10 | 10.35 ± 4.13 | 13.31 ± 5.04 | 0.000* | 0.042* | 0.006* | 0.000* |
| CD3+CD4+PD-1+ (%) | 4.97 ± 1.63 | 7.12 ± 2.93 | 9.24 ± 3.20 | 0.000* | 0.049* | 0.003* | 0.000* |
| CD3+CD8+PD-1+ (%) | 3.43 ± 1.35 | 4.53 ± 2.13 | 5.51 ± 2.22 | 0.012* | 0.138 | 0.011* | 0.005* |
| Immunohistochemistry | |||||||
| TILS(%) | 1(10.0%) | 17(20.5%) | 24(49.0%) | 0.001* | |||
| CD3 POSITIVE(%) | 1(10.0%) | 13(15.6%) | 21(42.9%) | 0.001* | |||
| PD-1 POSITIVE(%) | 0 | 12(14.5%) | 14(28.6%) | 0.038* | |||
P:statistical difference within each group, P1: NG&HT and PTC&noHT, P2: NG&HT and PTC&HT, P3: PTC&noHT and PTC&HT, * represents significant differences (p < 0.05)