Fig. 3.

Mutational landscape of identified clusters is concordant with that of clinical cohorts. Gene mutations in the five different subtypes of epithelial OC were identified from the literature (Additional file 1: Table S3 and references therein). Mutations in these genes were determined using the Cbioportal and visualised as an oncoprint diagram. Note: MCAS was shown separately to harbour a 127 base pair deletion in TP53 [28]. The track along the top indicates the subtype as identified by NMF of transcriptional profiling (Fig. 2). To the left, the tracks indicate whether a mutation has been identified in a cohort of patient samples of that subtype (see Additional file 1 for references)