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. 2021 Apr 22;106(9):2511–2515. doi: 10.3324/haematol.2021.278334

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Copyright© 2021 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 2. — Comparison of peripheral blood lymphocyte telomere length in patients with bone marrow failure. (A) Comparison of standard deviations (SD) in telomere length (TL) in patients with dyskeratosis congenita (DC), non-DC inherited bone marrow failure syndromes (IBMFS), and aplastic anemia (AA). Kruskall-Wallis and Holm tests were used to investigate the relationships among the three groups. P-values < 0.05 were considered statistically significant. (B, C) The cut-off values for TL were set according to the optimal combination of sensitivity and false positive rate (1-specificity) derived from receiver operating characteristic curves, which determined <−2.19 SD (very short TL) as the optimal TL threshold for evaluating DC patients, and <−1.71 SD (relatively short TL) for evaluating IBMFS patients, including non-DC patients. AUC, area under the curve.