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. 2021 Mar 25;106(9):2502–2506. doi: 10.3324/haematol.2020.278182

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Copyright© 2021 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 1. — sCD163 levels in two cohorts and correlation between pre-treatment sCD163 levels, CD163⁺ tumor-associated macrophages and CD163 mRNA levels in the trial cohort. (A) Comparison of sCD163 levels in pre-treatment and mid-treatment samples (after three courses) in the trial cohort, and in healthy volunteers. (B) sCD163 levels in pre-treatment samples compared to those in paired mid-treatment samples and paired post-treatment samples from patients in complete remission, and at primary progressive or relapsing disease in the population- based cohort. For graphical reasons the two extreme outliers with pre-treatment sCD163 levels over 11,000 ng/mL are not shown in the figure, but are included in the statistical analyses. (C) Correlation of pre-treatment sCD163 levels and CD163⁺ tumor-associated macrophages (TAM) in the tumor tissue in the trial cohort. (D) Correlation of pre-treatment sCD163 levels and CD163 gene expression levels from the matching tumor tissue in the trial cohort.