. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Circ J. 2016 May 6;80(6):1278–1284. doi: 10.1253/circj.CJ-16-0317

Table 1.

(A) Effect of Antioxidants or Antioxidant Enzymes in Animal Models of CVD, (B) Clinical Trials of Antioxidants in CVD

	CVD	Exacerbate	Improve
A
	MI	NAC (collateral growth)³⁵	Gpx overexpression,²¹ edaravone²²
	Ischemic reperfusion		SOD1, ²³ 2²⁴ and Gpx²⁵ overexpression, edaravone,²⁶ tempol²⁷
	Stroke		SOD1 overexpression,²⁸ edaravone²⁹
	HF		Probucol³²
	Hindlimb ischemia	Catalase overexpression,⁷ tempol⁶
	Ischemic preconditioning	SOD, N-2-mercaptopropionyl glycine³⁶
	CVD	Ineffective	Improve
B
	MI		Edaravone³⁰
	Stroke		Edaravone³¹
	HF	Vitamin E³³	NAC (renal failure)³⁴
	Prevention of CVD	Vitamins C and E, β-carotine⁴

CVD, cardiovascular disease; HF, heart failure; MI, myocardial infarction; NAC, N-acetyl cysteine.