Table 3.

Key characteristics of the main studies using radiomics and machine learning algorithms on magnetic resonance images to predict outcome other than pathologic complete response after neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Ref.	Study design (n of sites)	Number of patients	Prediction task	CT phase (n of CT scanner)	Segmentation method	ML algorithm	Data powering algorithm	Validation	Performance
Bibault et al[85], 2018	Retrospective (3)	99	pCR after nCRT	Unenhanced (3)	Manual – 3D	DNN	Radiomics and clinical features	Internal validation (cross-validation)	AUC: 0.72
Hamerla et al[86], 2019	Retrospective (1)	169	pCR after nCRT	Unenhanced (1)	Manual – 3D	RF	Radiomics features	Internal validation (cross-validation)	Accuracy: 0.87
Yuan et al[87], 2020	Retrospective (1)	91	pCR after nCRT	Unenhanced (1)	Manual – 3D	RF	Radiomics features	Internal validation (train/validation split)	Accuracy: 0.84
Wu et al[90], 2019	Retrospective (1)	102	MSI status	Venous phase - DECT (2)	Manual - 3 2D ROIs for lesion	LR	Radiomics features	Internal validation (train/validation /test split)	AUC: 0.87
Fan et al[91], 2019	Retrospective (1)	100	MSI status	Portal venous phase (2)	Semiautomatic – 3D	NB	Radiomics features	Internal validation (cross-validation)	AUC: 0.75
Wu et al[92], 2020	Retrospective (1)	173	KRAS mutation	Portal venous phase (3)	Manual + DL – single 2D ROI	LR	Radiomics features	Internal validation (train/test split)	C-index: 0.83
Wang et al[94], 2019	Retrospective (1)	411	Prediction of survival	Unenhanced (1)	Manual – 3D	10-F CV	Radiomics and clinical features	Internal validation (cross-validation)	C-index: 0.73

In all studies, three-dimensional manual segmentation of the primary tumor was performed to extract radiomic features, with the exceptions of Alvarez-Jimenez et al[113] (rectal wall), van Griethuysen et al[60] (semiautomatic segmentation) and Yang et al[115] (two-dimensional manual segmentation). ANN: Artificial neural network; AUC: Area under the receiver operating characteristic curve; CNN: Convolutional neural network; DWI: Diffusion-weighted imaging; EMLM: Ensemble machine learning model; GR: Good responders; LASSO: Least absolute shrinkage and selection operator; RF: Random forest; LR: Logistic regression; ML: Machine learning; MRI: Magnetic resonance imaging; QDA: Quadratic discriminant analysis; SVM: Support vector machine; T1w: T1-weighted; T2w: T2-weighted; TRG: Tumor regression grade.

10F-CV: 10-fold cross-validation; CT: Computed tomography; DECT: Dual-energy computed tomography; DNN: Deep neural network; LR: Logistic regression; ML: Machine learning; MSI: Microsatellite instability; NB: Naive Bayes; nCRT: Neoadjuvant chemoradiotherapy; pCR: Pathologic complete response; RF: Random forest.