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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Blood Cells Mol Dis. 2021 Mar 12;89:102561. doi: 10.1016/j.bcmd.2021.102561

Fig. 2. Benserazide increases HbF in older adult β-YAC mice.

Fig. 2

β-YAC mice (13–18 months old) were treated with water (Veh) and hydroxyurea (HU) controls and (R,S)-benserazide HCL (EEY), (R)-benserazide HCL (EF2) or (S)-benserazide HCL (EF3) test formulations (n=4). Blood was collected for flow cytometry analysis (See Methods). A) Shown are raw data for F-cells percentage (%) at week 0 (W0), week 2 (W2) and week 4 (W4). B) Shown are the fold changes in F-cells over time quantified by flow cytometry. C) To quantify fetal hemoglobin level per cell, the mean fluorescence intensity (MFI) was collected by flow cytometry. Shown are the MFI means over time. D) Shown is the fold change in MFI over time. For all data analysis significance was set at p<0.01 (*) or p<0.001 (**)