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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Blood Cells Mol Dis. 2021 Mar 12;89:102561. doi: 10.1016/j.bcmd.2021.102561

Fig. 5. Racemic benserazide increases F-cells in a dose-dependent manner.

Fig. 5

β-YAC mice (6–8 weeks old) were treated with water (Veh) and hydroxyurea (HU) controls and racemic (R,S)-benserazide HCL at 5, 20 and 30 mg/kg/dose (EEY5, EEY20, EEY30 respectively). Three treatment replicates (n=12) were combined and analyzed as described and blood collected for flow cytometry analysis (See Methods). Blood was collected for flow cytometry analysis. A) Shown are the raw data for the F-cells percent (%) at week 0 (W0), week 2 (W2) and week 4 (W4). B) Shown are fold changes in F-cells over same time-period. C) To quantify fetal hemoglobin level MFI was performed. Shown are MFI means over same time-period. D) Shown are fold changes in MFI over same time-period. Statistical analysis as described in Fig. 1; p<0.001 (***).