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. 2021 Jul 28;11(9):2490–2506. doi: 10.1002/2211-5463.13242

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© 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Screening for MDGs in CRC. (A) The methylation profile of the 30 most significant hypomethylated and hypermethylated MDGs in adjacent (n = 38) and CRC (n = 315) tissues. (B) The association between gene expression and DNA methylation of the top three hypomethylated and hypermethylated MDGs in CRC samples with both data available (n = 309). Pearson’s correlation analysis for each selected MDG was conducted (red line). (C) The mixture models of the top three hypomethylated and hypermethylated MDGs in adjacent (n = 38) and CRC samples (n = 315). The mixture components analyzed by the methylmix algorithm indicate the fitting curve of the distribution of the methylation values (β‐values) across all the samples (n = 353); the horizontal black bar represents the distribution of methylation values in the adjacent samples (n = 38).