FIGURE 5.

Hsa_circ_0042003 is upregulated in exosomes derived from U251R cells and the serum exosomes of temozolomide (TMZ)‐resistant glioma patients. A, Hierarchical clustering was used to identify differentially expressed exosomal circRNAs derived from U251 and U251R cells. B, Expression of hsa_circ_0041638, hsa_circ_0005963, hsa_circ_0037096, hsa_circ_0002782, and hsa_circ_0042003 in exosomes (exo) derived from U251 and U251R cells was analyzed using quantitative real‐time PCR (qRT‐PCR). C, Expression of hsa_circ_0041638, hsa_circ_0005963, hsa_circ_0037096, hsa_circ_0002782, and hsa_circ_0042003 in exosomes derived from serum of patients with and without TMZ‐resistant glioma was analyzed using qRT‐PCR. **P < .01; ***P < .001