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A scheme for progression of lung adenocarcinoma (LADC). During the progression process, one LADC can produce genetically heterogenous subpopulations. At first, driver mutations transform normal counterpart cells (N) to low‐grade neoplastic cells (L). While the neoplastic cells are proliferating, many additional mutations can occur, most of which might be nonfunctional passenger mutations, and some of which can be true progressors to produce high‐grade elements (H)
