TABLE 2.
Pyrosequencing results of individual CpGs and immunohistochemistry (IHC) results for determining MGMT status in glioblastoma
| Site | AUC (95% CI) | Cut‐off value (%) | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|
| Average | 0.709 (0.652‐0.768) | 12 | 60.1 | 72.2 |
| CpG 74 | 0.722 (0.655‐0.776) | 6 | 70.3 | 66.1 |
| CpG 78 | 0.705 (0.644‐0.763) | 5 | 67.7 | 64.4 |
| CpG 75 | 0.700 (0.642‐0.759) | 10 | 65.2 | 67.2 |
| CpG 80 | 0.700 (0.643‐0.760) | 5 | 76.0 | 60.0 |
| CpG 77 | 0.695 (0.634‐0.757) | 11 | 57.6 | 76.7 |
| CpG 76 | 0.687 (0.626‐0.750) | 5 | 73.4 | 58.9 |
| CpG 81 | 0.681 (0.624‐0.742) | 11 | 60.1 | 71.7 |
| CpG 79 | 0.677 (0.623‐0.744) | 9 | 65.2 | 67.2 |
| IHC | 0.653 (0.527‐0.768) | 30% | 73.4 | 58.9 |
Abbreviations: AUC, area under the receiver operating characteristic curve; CI, confidence interval.