FIGURE 6.

Anti‐tumor effect induced by CS‐pL‐Myc/pCAIX vaccine is dependent on CD8 T cell immune responses. In the depleted group of mice, 0.5 mg of anti‐mouse CD8 mAb was injected intraperitoneally at day −2, 5 and 12 after vaccination. (A) Tumor progression. (B) Tumor volumes. (C) Tumor weights. (D) Survival rate. (E and F) The proportions of CD8⁺ T cells and CD8⁺CD11c⁺ DCs in spleen or TILs. (G) Immunochemistry staining for CD8⁺ T cells of tumor tissues (×200 magnification). (H) Staining scores were analyzed in (G). The experiments were conducted with five mice per group. The data shown are the representative of three experiments. Data are means ±SD.**P <.01, ***P <.001