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. 2021 Aug 28;14:4967–4976. doi: 10.2147/IJGM.S321253

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© 2021 Liao et al.

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Cumulative rates of clinical relapse in patients with HBsAg levels <100 IU/mL and HBsAg levels ≥100 IU/mL. (A) An EOT HBsAg level < 100 IU/mL was associated with a lower risk of relapse after NA discontinuation. (B) Of patients with an EOT HBsAg level ≥100 IU/mL, those with an HBcrAg level ≥4.0 log₁₀ U/mL had significantly higher cumulative incidence rates of clinical relapse (78.1% vs 29.4%, p < 0.001). (C) Of patients with an EOT HBsAg level ≥100 IU/mL, those with an HBcrAg level ≥4.0 log₁₀ U/mL had significantly higher cumulative incidence rates of HBeAg reversion (29.4% vs 0%, p < 0.001).