Table 2.
Characteristics of Pneumococcal Meningitis Between 2012 and 2018, Stratified by PCV Serotypes
| Characteristics | Suspected Cases (n = 4007) | All Pneumococcus Detected (n = 156) | PCV10 Serotype (n = 24) | Non-PCV10 Serotype | P Valuea | ||||
|---|---|---|---|---|---|---|---|---|---|
| Pre-PCV (n = 607) | Post-PCV (n = 3400) | Pre-PCV (n = 46) | Post-PCV (n = 110) | Pre-PCV (n = 8) | Post-PCV (n = 16) | Pre-PCV (n = 20) | Post-PCV (n = 71) | ||
| Age groups | |||||||||
| Neonate | 71 (11.7) | 411 (12.1) | 0 (0) | 7 (6.4) | 0 (0) | 1 (6.2) | 0 (0) | 4 (5.6) | … |
| 1 mo to <1 y | 294 (48.4) | 1306 (38.4) | 35 (76.1) | 75 (68.2) | 7 (87.5) | 9 (56.2) | 17 (85) | 57 (80.3) | … |
| 1 to <3 y | 199 (32.8) | 1335 (39.3) | 10 (21.7) | 24 (21.8) | 1 (12.5) | 5 (31.3) | 2 (10) | 10 (14.1) | … |
| 3 to <5 y | 43 (7.1) | 348 (10.2) | 1 (2.2) | 4 (3.6) | 0 (0) | 1 (6.2) | 1 (5) | 0 (0) | … |
| Sex | |||||||||
| Male | 350 (57.7) | 1921 (56.5) | 26 (56.5) | 65 (59.1) | 3 (37.5) | 12 (75) | 13 (65) | 40 (56.3) | … |
| Female | 25742.3) | 1479 (43.5) | 20 (43.5) | 45 (40.9) | 5 (62.5) | 4 (25) | 7 (35) | 31 (43.7) | … |
| Mortality | 3 (0.49) | 225 (6.6) | 6 (13) | 14 (12.7) | 2 (25) | 4 (25) | 4 (20) | 9 (12.7) | … |
| CSF characteristics | |||||||||
| Turbid/cloudy | 21 (3.5) | 105 (3.1) | 11 (23.9) | 50 (45.5) | 3 (37.5) | 8 (50) | 7 (35) | 36 (50.7) | >.05 |
| White cells count, >100 cells/mm3 | 25 (4.1) | 102 (3) | 6 (13) | 34 (30.9) | 2 (25) | 5 (31.3) | 3 (15) | 33 (46.5) | >.05 |
| Protein >100 mg/dL | 35 (5.8) | 312 (9.2) | 10 (21.7) | 49 (44.5) | 3 (37.5) | 5 (31.3) | 6 (30) | 40 (56.3) | >.05 |
Data are No. (%).
Abbreviation: CSF, cerebrospinal fluid; PCV, pneumococcal conjugate vaccine.
aP value: PCV10 serotype and non-PCV10 serotype.